What is leaky gut and how does it relate to psoriasis?

Clinical perspective of leaky gut:

The gastrointestinal tract constitutes one of the largest sites of exposure to the outside environment. The function of the gastrointestinal tract in monitoring and sealing the host interior from intruders is called the gut barrier. A variety of specific and nonspecific mechanisms are in operation to establish the host barrier; these include luminal mechanisms and digestive enzymes, the epithelial cells together with tight junctions in between them, and the gut immune system.

Leaky-gut, Candida, antibiotic abuse, psoriasis, toxins

Disruptions in the gut barrier follow injury from various causes including nonsteroidal anti-inflammatory drugs and oxidant stress, and involve mechanisms such as adenosine triphosphate depletion and damage to epithelial cell cytoskeletons that regulate tight junctions. Ample evidence links gut barrier dysfunction to multiorgan system failure in sepsis and immune dysregulation. Additionally, contribution of gut barrier dysfunction to gastrointestinal disease is an evolving concept. An overview of the evidence for the role of gut barrier dysfunction in disorders such as Crohn’s disease, celiac disease, food allergy, acute pancreatitis, non-alcoholic fatty liver disease, and alcoholic liver disease is provided, together with critical insight into the implications of this evidence as a primary disease mechanism. DeMeo, Mark T., Mutlu, Ece A., Keshavarzian, Aliand, Tobin, Mary C. Intestinal Permeation and Gastrointestinal Disease. [Online] Available http://www.direct-ms.org/pdf/LeakyGutOther/DeMeo.pdf, June 27, 2008.


Leaky gut is a compromised immune system. Few people are born this way, but many more get it from too many infections, antibiotics, poor diet, parasites, and toxins. The combination of these things cause the lining of the bowl to become inflamed and thin. When this happens, larger particles get back into your body instead of being eliminated. Your skin works feverishly to remove these particles at a rate that is too quick for the natural sloughing process to take place. This results in psoriasis, dermatitis, eczema, acne, and many other non-skin related diseases.

The primary and most common cause of leaky gut is candidiasis. Candida is a yeast fungus that roots through the intestines causing porosity and proliferation of more yeast resulting in candidiasis. Because Candida is common in most people, the way is paved for infections, parasites, and toxins to flow through the leaks in your gut.

Antibiotics are said to destroy the healthy bacteria or flora in your gut. As a preventive measure, yogurt is an inexpensive and delightful way to ensure good digestive health, otherwise a good probiotic or L. acidophilus can be easily purchased to replenish the good bacteria. My daughter loves Nutrition NowRhino Chew FOS & Acidophilus Strawberry brand, which I purchase on line or from the more expensive Whole Foods store when I'm in a pinch.